The risk is higher when both copies of the gene are defective compared to Factor V Leiden carriers. How much good can your data do? This can be a life-threatening situation. If abnormal clots become an issue, "blood-thinning" medications, like Coumadin, can be used to impair the clotting system.
We do not endorse non-Cleveland Clinic products or services. Know the causes, symptoms, treatment, prevention, prognosis, complications of factor V deficiency or owren's disease Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot.Some clots do no damage and disappear on their own. Pulmonary embolism occurs when pieces or fragments of a blood clot – usually from a DVT of the leg - break off and travel to the vessels in the lungs.The mutation is named factor V “Leiden” because it was originally discovered at the University of Leiden in the Netherlands, in 1994.FVL can only be inherited from a parent who has the mutation, which is more common among individuals of Northern European ancestry. Cleveland Clinic is a non-profit academic medical center. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening.Both men and women can have factor V Leiden. In the lung, large clots impede the normal exchange of oxygen and carbon dioxide.
Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Some will have a family history of deep vein thrombosis/pulmonary embolism (DVT/PE) but will never have an abnormal blood clot in their lifetime. It is important to recognize PE early because a large blood clot in the lungs can cause damage to the heart and in very rare cases PE can be a fatal condition in pediatric patients.In this Helping Hand™ document, we discuss Factor V Leiden, which is an inherited blood disorder. National Blood Clot Alliance. Because each protein in our body is made by two different genes (one inherited from Mom, one inherited from Dad), there are two types of FVL: “People who are born with FVL are at higher risk of developing DVT and PE. Factor V Leiden is a genetic disorder. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.Most people with factor V Leiden never develop abnormal clots. In these situations, abnormal blood clots can become life-threatening.Since Factor V Leiden is an inherited condition, there is no way to prevent it. In This Section
The factor V Leiden mutation does not itself cause any symptoms. Children born with Factor V Leiden produce a mutated form of Factor V that does not respond well to activated Protein C. This may lead to abnormal clot formation. These blood clots can be life-threatening.Mayo Clinic does not endorse companies or products. This high incidence prevalence mirrors the incidence in the corresponding general populations and can be even higher in … Watch Queue Queue UK prices shown, other nationalities may qualify for reduced prices. However, there are certain lifestyle changes one can make to reduce the risk of abnormal clot formation. The vast majority of those affected with Factor V Leiden will never encounter a problem and most will never be aware they are affected.